Cables1is a tumor suppressor gene that regulates intestinal tumor progression inApcMinmice

A New Tumor Suppressor That Regulates Tissue Architecture

Pathologists use loss of normal tissue architecture as a key criterion to identify and categorize disease states. Epithelia in all glandular structures in vivo have a characteristic organization where they line a central lumen and are involved in absorptive and/or secretory functions. Under some physiological conditions— such as pregnancy, wound healing, and the periodic tissue remodeling that ...

DLC1: a tumor suppressor that regulates Rho signaling

The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration.

Identification of the signaling pathways that control the proliferation of stem cells (SCs), and whether they act in a cell or non-cell autonomous manner, is key to our understanding of tissue homeostasis and cancer. In the adult Drosophila midgut, the Jun N-Terminal Kinase (JNK) pathway is activated in damaged enterocyte cells (ECs) following injury. This leads to the production of Upd cytokin...

Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression.

Epidemiological and experimental observations support the hypothesis that chronic inflammation contributes to cancer development and progression; however, the mechanisms underlying the relationship between inflammation and cancer are poorly understood. To study these mechanisms, we have transfected the mouse 4T1 mammary carcinoma with the proinflammatory cytokine IL-1beta to produce a chronic i...

Inactivation of SMAD4 tumor suppressor gene during gastric carcinoma progression.

PURPOSE Mothers against decapentaplegic homologue 4 (SMAD4) is a tumor suppressor gene associated with gastrointestinal carcinogenesis. The aim of the present study is to more precisely characterize its role in the development and progression of human gastric carcinoma. EXPERIMENTAL DESIGN The expression of SMAD4 was investigated in 283 gastric adenocarcinomas and related lesions, as well as ...